Recent versions of Wine are actually pretty darn nice. There are still a few issues with Wine audio and PulseAudio, but from my research has uncovered, this is due to really obscure bugs on both sides. Thankfully though, these sorts of bugs are rare now a days.
Anyways, what I am using my laptop for. I would like this to a moderate gaming rig, so a moderate GPU would be nice. Also, I am planning on using this computer for background computation stuff (like BOINC), so a OK GPU and good CPU would be nice. And finally, I am gonig to be doing some dev work on it, so good memory, like 6GB will, and a good CPU will do. I am pretty good about keeping my disk usage in check, so I don't need anything more than 400-500 GB.
All in all, I am looking for a mid-high range system.